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Biochem Pharmacol 34:11851189

While GTs initiate extracellular GSH breakdown, the primary intracellular degradation pathway is now thought to be mediated by the cationic transport regulator homolog (ChaC)-like family of -glutamylcyclotransferases (GCT) ( ChaC-like family proteins are remarkably conserved, being found across all phyla from bacteria to humans, where they catalyze intracellular GSH degradation and yield 5-oxoproline and cysteinylglycine (Figure 2)

albicans hyphae, yet binding of albumin was almost absent in an als3 mutant (Fig

These mediators not only drive neuroinflammation but also directly damage myelin and oligodendrocytes

I., Irizarry, R