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The choice of an ideal fluorophore is not a simple task

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Mitragynine exhibited moderate affinity at - and -opioid receptors whereas 7-hydroxymitragynine showed strong affinity at the - opioid receptor (14X greater than mitragynine) and moderate affinity at the - and -opioid receptors (4X and 70X greater than mitragynine)

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase