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Transforming growth factor- (TGF-) is known to promote fibrosis and contribute to POF (Persani et al., 2011), and collagen content and fibroblast proliferation are significantly reduced, which is related to AMPK-mediated suppression of TGF- production after metformin administration (McCloskey et al., 2020)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Man AL, Bertelli E, Rentini S, Regoli M, Briars G, Marini M, Watson AJM, Nicoletti C

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