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Outcomes appear highly context-dependent, reinforcing the need for controlled experimental design and continued mechanistic research

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Against this background, this review provides an overview of the structure and function of the bloodbrain barrier and discusses the abnormal changes in the BBB in different CNS diseases

Full therapeutic doses are a separate and more promising story, now in trials for depression and, as covered above, in an early test in Parkinsons

These include: Paraesthesia (pins and needles) in hands and feet Peripheral neuropathy with numbness or altered sensation Difficulty walking or balance problems (ataxia) Memory problems and cognitive difficulties Mood changes, including depression or irritability In severe cases, confusion or dementia-like symptoms Other manifestations may include: Loss of appetite and unintentional weight loss Constipation Visual disturbances (rare, but can occur with optic neuropathy) Important: The neurological complications of B12 deficiency can progress even in the absence of anaemia, making early detection crucial