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According to the Global Burden of Disease (GBD) Study 2019, the number of individuals living with PD more than doubled from 2.5 million in 1990 to over 6.1 million in 2016, with projections exceeding 12 million by 2040 (Zhong and Zhu, 2022)

Somatostatin is also produced by several other populations that project centrally, i.e., to other areas of the brain, and somatostatin receptors are expressed at many different sites in the brain