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During this process, the heme responsive gene-1 (Hrg1) is specifically recruited to the phagolysosomal membrane, where it strongly co-localizes with the lysosomal marker Lamp1 (91, 92)

In addition, DOT1L is the only histone lysine methyltransferase responsible for H3K79 methylation which can promote the occurrence of leukemia

Here, we report that the combination therapy of As 2 O 3 with L-buthionine-sulfoximine (BSO), which inhibits a critical step in glutathione synthesis, effectively enhanced in vitro growth inhibition effect of As 2 O 3 on all 11 investigated cell lines arising from prostate, breast, lung, colon, cervix, bladder, and kidney cancers, compared with As 2 O 3 treatment alone

Neuron death was associated with reduced electron transport chain function, particularly mitochondrial cytochrome c oxidase, [158] which was proposed to derive from the preferential delivery of Cu to human SOD1 at the expense of cytochrome c oxidase

Modulation of endometrial redox balance during the menstrual cycle: Relation with sex hormones