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[0181] In some embodiments, the one or more cofactors or precursors thereof is selected from nicotinamide adenine dinucleotide, Flavin adenine dinucleotide (FADH 2 ), Flavin adenine dinucleotide phosphate, alpha-lipoic acid, acetyl-l-carnitine, niacinamide (vitamin B3), nicotinamide adenine dinucleotide phosphate (NADPH), thiamine, riboflavin, niacin, pyridoxine, cyanocobalamin, biotin, folic acid, pantothenic acid, vitamin C, thiamine pyrophosphate, flavin mononucleotide, pyridoxal phosphate, doexyadenoxylcobalamin, methylcobalamin, tetrahydrofolate, and coenzyme A

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