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For example, individuals maintaining a vegetarian or vegan diet for a minimum of 3 months demonstrate significant and enduring shifts in microbial structure and microbiome-related immune parameters compared to those adhering to these diets for shorter periods

Anandachockalingam, A., et al

Vitamin C clearly shows this limitation - you only absorb about 20% orally compared to almost 100% through IV administration

& Roberts, V

Model-optimized fluconazole dose selection for critically ill patients improves early pharmacodynamic target attainment without the need for therapeutic drug monitoring