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While glutathione binds toxins and protects cells, alpha-lipoic acid regenerates used glutathione, enhancing detoxification capacity

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Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly YM, Glickman JN, Garrett WS (2013) The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis

Osteoblastic responses to LPS, glucose-oxidised LDL and minocycline: Therapeutic targets for periodontal and cardiometabolic diseases

With very high-dose, long-duration daily glutathione supplementation, some research suggests the body can downregulate its own internal production enzymes (GCLC and GCLM) because abundant exogenous supply tells the cell it doesnt need to make as much