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Upregulated expression of 17-hydroxysteroid dehydrogenase 1, a key enzyme for E2 production, is observed in the in situ endometrium, accompanied by high estrogen levels, which are responsible for a high rate of implantation failure in patients with infertile ovarian endometriosis (5)

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Typical Course and Comorbidities IC/BPS is most commonly diagnosed in individuals over 40, although the diagnosis may be delayed depending upon the index of suspicion for the disease, and the criteria used to diagnose it

To do this, eat a nutrient-dense diet, exercise, sleep enough and take high-quality vitamins that act as methyl donors.