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AMPK activation is triggered by a decrease in the ATP/AMP ratio, leading to SIRT1-mediated deacetylation and suppression of HIF-1 activity, thereby attenuating glycolysis (Price et al., 2012)

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Role of polyunsaturated fatty acids and lipid peroxidation on colorectal cancer risk and treatments

10.1016/j.biopha.2018.02.064 43 EsmaeilN.AnarakiS

The 20 C-terminal residues of one monomer mainly interact with the N-terminal end of helix 5 and with the C-terminal end of helix 6 of the other monomer, allowing the formation of a dimer that completely differs from the usual GST dimer (Figure 5F) (Meux et al., 2011)