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This makes combination therapy particularly attractive in resistant cases or where long-term results are needed

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At clinical doses under supervision, the most common side effects are mild nausea in the first week (typically resolves by day 7 to 10), injection site reactions (redness, minor swelling, localized soreness lasting 24 hours), and occasional transient fatigue or mild headache in the first few days

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Increased collagen deposition and angiogenesis were observed in treated wounds, and T4 stimulated keratinocyte migration 23-fold in Boyden chamber assays at concentrations as low as 10 pg results that identified T4 as a potent, multi-mechanism wound healing factor