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Because it interacts with so many different biological systems, any impurity could trigger an unforeseen cascade of events

But epidemiologic data suggests otherwise

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Certain MC1R variants reduce the capacity for repair to damaged DNA [5], while the process of melanin biosynthesis, particularly of pheomelanin, may itself generate reactive oxygen species and other by-products that may be cytotoxic, genotoxic, or mutagenic causing DNA damage [4, 6]