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In ancient China, based on the experience of using medicinal botanical drugs, natural plants with medicinal properties were compiled into books such as Shennongs Classic of Materia Medica, Newly Revised Materia Medica, and Compendium of Materia Medica. Various plants were classified according to experience and used for targeted treatment of various diseases ( Gastrodia elata ) as an example, the earliest recorded pharmacological work on Tianma is in Shennongs Classic of Materia Medica. Over 2000 years ago, Tianma was already used for the treatment of cardiovascular, neurological, and nervous system diseases

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54) plus 100 M sodium iodide, when combined together, triggered the appearance of Annexin V positivity within 4 hours (Figure 6A, quantified in 6B)