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Metabolomics analyses revealed a time-dependent increase in tricarboxylic acid cycle intermediates during ES treatment, suggesting that copper toxicity primarily disrupts the tricarboxylic acid cycle rather than oxidative phosphorylation (180,181)

PengXWangXShaoXWangYFengSWangCet al

with Arg242 and Arg257 of VP1 from neighbouring protomers in the interface conferring strong positive charge characteristics to the GSH-binding pocket and forming hydrogen bond and saltbridge contacts with the carboxy terminus of GSH (Fig