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R Substrates conjugated with amino acids include: Benzoic acid (from toluene exposure, food preservatives, and gut bacterial metabolism of polyphenols), conjugated with glycine to form hippuric acid R Bile acids (conjugated with glycine or taurine for proper emulsification and excretion) R NSAIDs and other acyl group drugs Phenylacetic acid (from phenylalanine metabolism), conjugated with glutamine to form phenylacetylglutamine R Salicylic acid (aspirin metabolite), conjugated with glycine to form salicyluric acid R Glycine conjugation is the most common amino acid conjugation

Proc Natl Acad Sci U S A 99(26):1674216747 Pluta R, Uamek-Kozio M, Januszewski S, Czuczwar SJ (2018) Tau protein dysfunction after brain ischemia

The first pathway involves a series of addition reactions, including hydration, hydrogenation, and the addition of aldehyde groups to the AFB1 molecule, driven by the activity of reactive species generated by HVACP, such as hydrogen atoms and hydroxyl radicals