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Many patients titrate up to 50 to 100 mg per dose 2 to 3 times per week as tolerated

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A recent report showed that higher adhesion to primary lung fibroblasts is associated with escalation of intrinsic and acquired chemoresistance in epithelial ovarian cancer cells, and is largely governed by 6 integrin-IGF-1R dual signaling axes (32)

NLR is likely to be associated with disease progression, and may provide a useful criterion for gauging the efficacy of molecularly targeted agents

There's no required washout period