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These findings highlight the necessity of systematic toxicological assessments and long-term clinical follow-ups, especially in vulnerable populations, such as children, pregnant women, and patients with chronic illnesses

However, much of the research on BPC-157 has been conducted in animals, and key questions about safety, effectiveness, dosing, and long-term outcomes remain unanswered

Furthermore, investigating the relative degree of tumor dependency on exogenous glutamine at distinct stages of tumorigenesisthat is, in the primary tumor initiation and expansion, local tissue invasion, survival in the circulation and seeding, and colonization of distant organsmay provide further insights into the therapeutic potential of targeting glutamine metabolism in cancer therapy

doi: 10.1016/S0140-6736(15)00807-7 9 OlotuAFeganGWambuaJNyangwesoGLeachALievensMet al

State of the Art Treatment for Head and Neck Cancer 2016