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TAC surgery was associated with the upregulation of the hypertrophic cardiomyocyte biomarkers atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and -myosin heavy chain (-MHC), whereas these levels were significantly decreased in cardiac tissue samples from PQQ-treated mice that underwent TAC surgery (Figure 1J)

SalA normalized several of these molecular alterations, restoring transcription networks that maintain redox and metabolic balance

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The N-hydroxyamide products are reactive and can lose a water molecule to produce a reactive N-acetylimidoquinone (an imine)(NAPQI)