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doi: 10.1016/j.chembiol.2020.03.014 14 BellJ

doi: 10.1016/j.canlet.2019.11.019 30 ChenG.RanX.LiB.LiY.HeD.HuangB.et al

Additional precautions include sedation, dizziness, tremor, weight gain, and potential metabolic effects (e.g., changes in appetite or polycystic ovary syndrome features)

Two interested parties noted there could be unintended consequences to patient access if the measure was adopted

It promotes lipid uptake by modulating lipid transporters CD36, FABPs, and FATPs, while stimulating lipogenesis through transcriptional activation of lipogenic enzymes such as lipoprotein lipase (LPL) ( 2.3 Carbohydrate response element binding protein (ChREBP) ChREBP is a transcription factor that promotes lipogenic gene expression by sensing carbohydrates and is a hub for hepatic lipid synthesis ( 2.4 Farnesoid X receptor (FXR) The nuclear receptor superfamily member, FXR, exists as four principal human isoforms (FXR1-4), with predominant hepatic and intestinal expression