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It includes extensive biological changes from the genomics to proteomics ( It is important to note that metformin can significantly affect the levels of various metabolites, including those involved in the glucose metabolism, lipid metabolism, tricarboxylic acid cycle (TCA), and urea cycle ( A study by Safai et al
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J Bacteriol 178 , 19905, doi:10.1128/jb.178.7.1990-1995.1996 (1996)
