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However, hives can also develop in response to: Infection Extreme temperature changes Sun or sweat exposure Stress and anxiety Hormone changes Physical stimuli like pressure, vibration, or sunburn Medical procedures like laser hair removal So in rare cases, the heat, vibration, or pressure from a laser hair removal treatment can trigger the release of histamine and a hive-like reaction

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Medically reviewed by Lauren Okafor | MD , The Frank H Netter MD School of Medicine, Loyola University Medical Center on March 16th, 2026

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These symptoms are often similar to those associated with MTHFR genetic mutations and may come from nutritional deficiencies affecting methylation