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8 Conclusion Compelling scientific evidence now establishes that environmental endocrine disruptors pose profound threats to male reproductive health through complex molecular mechanisms involving hormonal disruption, oxidative stress induction, mitochondrial dysfunction, and epigenetic modifications

Concomitantly, intensified research efforts should prioritize the investigation of royal jelly acid derivatives, particularly diHDA-glycerol derivative of royal jelly acid

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In laboratory and pre-clinical settings, DSIP has been studied as a uniquely multifunctional endogenous regulatory neuropeptide across sleep, stress, neuroendocrine, neuroprotection, and geroprotective research applications: Sleep biology delta-wave SWS promotion, sleep homeostasis modulation, sleep efficiency and sleep latency research Sleep EEG research delta-wave induction, SWS vs REM sleep architecture, and sleep stage analysis via polysomnography Sleep neuromodulator pharmacology DSIP vs sedatives and hypnotics