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SIRT2, as one of the HDACs, has been shown to possess multiple deatylation enzyme activity, including deaceylation [35], decrotonylation [39], demethacrylation [40] and delactylation [41], and regulate a variety of biological processes, such as suppressing glycolysis [42], maintaining redox balance [43], and promoting cell cycling and division [44]

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Xie S, Li S, Chen B, Zhu Q, Xu L, Li F (2021) Serum anti-citrullinated protein antibodies and rheumatoid factor increase the risk of rheumatoid arthritisrelated interstitial lung disease: a meta-analysis

Glutathione supplementation has no apparent effect on the immune system in health, but it does benefit in the setting of disease, even in the setting of simple viral illnesses

The db/db mouse contains a mutation in the leptin receptor, which impairs its normal function regulating appetite, leading to obesity and insulin resistance