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OS is a state of imbalance between oxidation and antioxidant defense in the body, tending towards oxidation, leading to neutrophil inflammatory infiltration, increased protease secretion, and the production of large amounts of oxidative intermediates 8

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[44,109] Table 1: Gene Therapy Gene therapy represents a promising therapeutic option for patients with porphyria

LC-MS/MS conditions Experiments were carried out on ThermoFisher Scientific Vanquish high-performance liquid chromatography connected to ThermoFisher Scientific TSQ Quantis triple quadrupole mass spectrometer

A synergistic effect was observed in cell inhibition percentages greater than 21.5% in DLD-1(KRAS G13D/- ) and 17.6% in Caco-2-CR cells