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A threshold for uMMA/C ratios of 1.45mol/mmol has been established for adult patients with plasma B12 concentrations in the low-normal range (i.e., 201350ng/L)

Constipation is not listed as a recognised side effect in UK product information for vitamin B12 supplements or injections

Older adults, who often suffer from decreased hydrochloric acid in the stomach, and individuals with gastrointestinal (GI) disorders may have lower absorption of B12.2,4 Vitamin B12 deficiency may be characterized by megaloblastic anemia, fatigue, weakness, constipation, loss of appetite, soreness of the mouth or tongue, and weight loss

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