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Many age-related changes in circadian rhythms and sleep architecture, such as reduced rhythm amplitude, phase advance, and altered sleep consolidation, may reflect adaptive remodeling of the circadianhomeostatic system rather than intrinsic dysfunction (Videnovic et al., 2014)

This intrinsic oxidative vulnerability of the brain and growing evidence of neurodegenerative changes associated with many psychiatric syndromes suggests that oxidative damage may be a plausible pathogenic candidate

The magnitude of this increase is difficult to predict a priori according to the different midazolam formulations (oral vs parenteral) and degree of disease severity (IL-6 levels) [88]

Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes