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[,] Advance cirrhosis or acute liver failure induces marked renal dysfunction characterized by reducing renal blood flow and glomerular filtration rate (GFR), and this has been referred to as hepatorenal syndrome (HRS). [,] Conventionally, HRS occurs in two different clinical patterns, type 1 HRS (HRS-1, characterized by abrupt impairment of renal function that often occurs because of a precipitating event) and type 2 HRS (HRS-2, a moderate and stable or slowly progressive renal dysfunction often occurs without an obvious precipitant, and it is associated with refractory ascites)

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This approach enhances treatment efficacy, overcomes resistance, and reduces required doses, minimizing side effects