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In the absence of recurrent episodes, the dose can be gradually tapered, and the anti-H1 may eventually be discontinued, since as in CSU, some patients may enter remission [25]

Figure 3D shows phase-delayed diurnal expression of RLC transcripts

If the second step is also tumor-selective, the toxic payload will be generated only in tumor cells, whereas all healthy cells are not harmed because they contain only the inactive payload