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To validate whether the exogenous addition of glutamate and -KG nourish the TCA cycle, the enzymatic activity of OGDH, the first rate-limiting enzyme of -KG entry into the TCA cycle, was determined

Reduced SOD activity further reflects impaired antioxidant defenses when challenged, as antioxidants are overwhelmed in attempting to neutralize ROS

Both PAM212 keratinocyte co-culture and IMQ-induced psoriasis-like mouse models demonstrated that NETs inhibition closely correlated with reduced inflammatory responses, supporting the proposed mechanism

Beijing: Chinese Medicine and Science Publication House

In the FAS population, the median GSH concentration appeared artificially higher in the placebo (459 mol/L) than in the NAC (402 mol/L) group, due to imputation method for missing values (15%-NAC and 5%-Placebo) (Fig