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107 Correspondingly, there were also histone demethylases have been identified, the enzymes of the histone-lysine demethylase group are divided into two main families: KDM1, which includes two members (LSD1/KDM1A and LSD2/KDM1B), and JmjC-containing HDMTs, which consist of several subfamilies with more than 30 proteins totally

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