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Carbonyl stress has low severity in the early stages of renal failure, which may make amlodipine ineffective in lowering AGEs/RAGE

12 15] 4 Case Reports/Case Series [16 19] 1 Prospective Trial [20] Dexemedetomidine does not protect against withdrawal seizures and should not be used as monotherapy Ketamine 1 Retrospective Review [21] Clinical Bottom Line Phenobarbital, propofol, and dexmedetomidine have been shown to reduce benzodiazepine requirements in AWS Nothing has proven to shorten AWS duration or ICU LOS Dexmedetomidine does not protect against withdrawal seizures and should not be used as monotherapy References: Rosenson J et al