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These inhibitors induce ferroptosis by blocking cystine uptake via SLC7A11 and fall under the category of class I ferroptosis inducers

Dysregulation of ROS homeostasis can impair cellular and organismal physiology, ultimately contributing to disease pathogenesis, which is a phenomenon observed throughout the lifespan

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Clinical research demonstrated that AOD-9604 had no effect on serum IGF-1 levels, confirming that the peptide fragment does not activate the traditional growth hormone receptor pathway