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The use of the appendix diameter as a diagnostic tool is advantageous because of its non-invasive nature and ease of measurement through imaging modalities such as ultrasound and CT scans

Hum Mol Genet 2015;24:252838

It is synthesized intracellularly as a 31 kDa precursor form, pro-IL-1, which is cleaved by Caspase-1, activated by inflammasomes (such as NLRP3, NLRC4, AIM2, etc.) into a 17 kDa mature form, and is subsequently released from the cell through non-conventional secretion [342]

Proper dosing, administration, and handling are key to ensuring reliable results and maintaining the integrity of the peptides