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These findings show that lineage-directing transcription factors such as HNF4 regulate metabolic enzymes such as OGDH, and that this interaction is essential for enterocyte energy balance and survival

It is unclear whether any enhanced erythropoietic effect caused by androgens would confer clinical benefits that outweigh the potentially significant AEs of androgens or the effects of simply allowing patients to remain at somewhat lower Hb levels without androgens

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