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Moreover, it has been proposed that 4-HNE can induce cell death by modulating several transcription factors, such as Nrf2 and peroxisome proliferator-activated receptors (PPARs), as well as other signaling pathways, such as cell-cycle regulators and caspases [57]

In both panels, blots were normalized against -actin levels that were determined in matching gels run under reducing conditions

38 In terms of NADKs activities, cNADK phosphorylated at S44, S46, and S48, which may be mediated by the phosphoinositide 3-kinase (PI3K)Akt signaling, has enhanced activity in breast cancer and lung cancer cells, thereby increasing NADPH production