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NADPH is required for protein, DNA, and RNA synthesis ( One-carbon metabolism While early studies in immune cells demonstrated glycolysis to be the predominant metabolic pathway ( de novo purine synthesis, methyl donor generation, as well as NADPH production that are critical for cell survival and function ( de novo nucleotide synthesis ( 13 C 2 -serine labeling of the media used to stimulate nave T cells with tracing through the pathway to the yield of 13 C labeled purines

10.3390/biology12020196 151 RodaE.PrioriE

the molecule may not be absorbed effectively in the digestive tract the dose may be too small to influence cellular physiology the compound may break down before reaching target tissues the body may rapidly eliminate it through the liver or kidneys Even when a compound is absorbed into the bloodstream, that does not necessarily mean it will influence cellular biology

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