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accordingly, glutamine synthetase (GS), which promotes glutamine synthesis from glutamate, restrains both M1 macrophage differentiation and antitumor immunity, and its inhibition promotes implanted lung tumors elimination in mice [50, 182]

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Topical administration refers to the application of a pharmaceutical agent to the external surface of the skin or the mucous membranes (including the surface membranes of the nose, lungs and mouth (in which case it may also be a form of oral administration, such that the agent crosses the external surface of the skin or mucous membrane and enters the underlying tissues

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Brought on by the suppression of POLG expression and the overexpression of TFAM, the findings indicate that the overall toxicity was partially linked to the reduction in mtDNAcn

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