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The key role of GSH as an antioxidant is demonstrated by many studies showing that experimental depletion of GSH levels which can be achieved with various chemicals the most used of which is buthionine sulfoximine (BSO) an inhibitor of GSH synthesis has a worsening effect in many disease models

El glutatin, conocido como el antioxidante maestro, junto con la L-cistena, acta neutralizando los radicales libres que daan las clulas

5I), indicating that the Ufd4-mediated K29-linked ubiquitin chain is not involved in the RQC induction

The middle section highlights future precision targeting strategies, such as phage therapy for the precise clearance of pathogens like Klebsiella, engineered bacteria for the synthetic delivery of therapeutic molecules (e.g., IL-10), and microbial enzyme inhibitors targeting pathways like CutC/D to reduce harmful metabolites such as TMA/TMAO

Depletion of a discrete nuclear glutathione pool by oxidative stress, but not by buthionine sulfoximine