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They act to increase the basal metabolic rate, affect protein synthesis, help regulate long bone growth (synergy with growth hormone) and neural maturation, and increase the body's sensitivity to catecholamines (such as norepinephrine and epinephrine) by permissiveness, especially under cold exposure

Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency

Exercise activates adipose Ppar, which binds the Peroxisome Proliferator Response Element (PPRE) in the Nrg4 promoter to drive Nrg4 transcription

*-OHdG is widely used as a marker of oxidative stress and other degenerative conditions