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Small RNA profiling of piRNAs in colorectal cancer identifies consistent overexpression of piR-24000 that correlates clinically with an aggressive disease phenotype

doi: 10.1038/ijo.2012.48 237 DavidLAMauriceCFCarmodyRNGootenbergDBButtonJEWolfeBEet al

Creates the conditions for the alignment of regional development with knowledge (Foray, 2004) and mission economy (Mazzucato, 2021)

For liver-specific genetic deletions, mice were injected via the tail vein with 2.510 11 GC of AAV-TBG-Cre (Addgene, 107787-AAV8) in PBS

The effect was dose-dependent, with subcutaneous administration at 15 mg/kg showing significant reductions in fasting glucose and HbA1c markers