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The analysis revealed that metabolic genes, particularly members of the solute carrier (SLC) family such as SLC25A10, SLC25A1, SLC22A1, SLC7A8, and SLC7A9 exhibited comparatively higher expression in HIV-MNO as compared to the other groups (Fig

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This has been attributed to increased mechanical fragility (iron deficient RBC are more rigid and more likely to fragment as they traverse through small capillaries under high shear), however oxidative injury to red blood cells is likely contributing to keratocyte formation (Yoo et al 2009) (given that antioxidant enzymes in red blood cells, such as glutathione peroxidase, contain iron)

PMID 30405529

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