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While studies attempting to localize the pathology in FMS to peripheral tissues have failed in showing any abnormalities in muscle tissue, Staud and coworkers did show that enhanced central pain processing can occur via continued peripheral muscle afferent input, Their study demonstrated that muscle lidocaine injections increased local pain thresholds and decreased remote secondary heat hyperalgesia in fibromyalgia patients, emphasizing the important role of peripheral impulse input in maintaining central sensitization

How does GLP-1/GIP + B12 help with weight loss

Using spoiled B12 injections may affect potency and safety

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Initiate supplementation with oral folic acid and intramuscular vitamin B12 prior to the first dose of PEMFEXY