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LiRYangYWangHZhangTDuanFWuKet al

PrimeView Published: Meniere's disease Nature Reviews Disease Primers volume 2 , Article number: 16029 (2016) This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 1 digital issues and online access to articles $119.00 per year only $119.00 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

10.1186/s13229-017-0183-3 140

Furthermore, therapeutic agents targeting mitochondrial enzymes such as SHMT2, PDH, and CPT1A remain largely in preclinical or early-phase clinical development, with limited data available on optimal delivery strategies, pharmacokinetics, and safety profiles [24]