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A feedback inhibition by cysteine decreased SERAT1;1 and -3;1 activity but appeared to have no impact on the three other SERAT isoforms (Figure 2 and Supplementary Table 2

This complex is redox-inactive, making it a safe and effective molecular vehicle for delivering bioavailable copper in experimental settings

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For the von Frey test, rats ( n = 84) were placed in a Plexiglas chamber (10 20 20 cm) placed on a wire grid floor, and the plantar surface of the hindpaw was stimulated using an electronic von Frey anesthesiometer (Electronic von Frey 2390, IITC Life Science)

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