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Conclusions Colorectal carcinoma is characterized by increased oxidative stress and antioxidant disbalance

This heterologous desensitization characterized by an uncoupling of G proteins from DOR is neither associated with modifications in receptor number nor in their phosphorylation but involves several kinases [cAMP-dependent protein kinase (PKA), MAP kinases/ERK kinase 1 (MEK1) and phosphoinositide-3 kinase (PI3K)] that could phosphorylate signaling proteins (Xu et al., 2013)

These, along with pollution and other external elements such as stress, can cause premature ageing of the skin due to oxidative stress that usually manifests itself in visible signs such as wrinkles, dark spots, loss of firmness