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Based on these data, it was estimated that 7.013.2% of ZEN is excreted within 24 h via urine as ZEN and ZEN conjugates, while 1020% of the dose is excreted as the sum of ZEN, -ZEL, -ZEL, and their conjugates (Metzler et al

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Given the safety and promise of this treatment, combined with the paucity of other effective treatments for emphysema, we suggest this treatment be considered for widespread use