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Carica papaya extract stimulates Nrf2 in a mechanism that depends on the interaction of the Carica papaya flavonoids with the Nrf2 binding pocket of keap-1, leading to release of Nrf2 and its nuclear accumulation (Kumar et al., 2024)

Completing the process, the autophagosome fuses with the lysosome, forming the autophagolysosome in which the acidic environment for cargo degradation is maintained by the activity of the lysosome-resident vacuolar [H + ]-ATPase (V 0 -ATPase) proton pump