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The integrin 1/5/JNK/c-JUN signaling pathway in cancer cells is able to upregulate the higher matrix stiffness-induced lysyl oxidase like (LOXL)-2, then subsequently promote production of fibronectin, expression of MMP-9 and C-X-C motif chemokine ligand (CXCL)-12 and recruitment of BMDCs to encourage pre-metastatic niche establishment (95)

20 , 18951902 (2007) Raghunathan, S., Chandross, J., Kretsinger, R.H., Alliston, T.J., Penington, C.J., Rule, G.S.: Crystal structure of human class mu glutathione transferase GSTM2-2

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It appears to modulate dopamine receptor sensitivity and protect against dopamine-depleting agents