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Pregnancy considerations: Tirzepatide is not recommended during pregnancy, and women of childbearing potential should be advised that tirzepatide may reduce the effectiveness of oral contraceptives, particularly during initiation and dose escalation

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A peptide half-life chart lists the time required for the plasma concentration of each peptide to decrease by 50% after administration

Furthermore, treatment of 5FAD mice with hippocampal neuron-derived EVs effectively mitigated cognitive decline, as assessed by the Rotarod test for motor coordination, OFT for locomotor and exploratory activity, and contextual fear conditioning for memory [22]